circRNA basic information
circBase ID: -
Name: hsa_circ_PTPRA
Synonym: circ_PTPRA
Host Gene: hsa-miR-671-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human CRC cell lines (HCT116, DLD1), normal colonic epithelial cell line (NCM460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-671-5p
Biological function: Exosomal circ_PTPRA induced CRC cell cycle arrest and inhibited cell proliferation.
Molecular mechanism: circ_PTPRA functioned as a competing endogenous RNA (ceRNA) to increasing SMAD4 level by binding to hsa-miR-671-5p.
Survival: -
Supported No.:
 1
Description:

Exosomal circ_PTPRA enhanced CRC cell radiosensitivity and inhibited CRC malignant development partially by regulating the miR-671-5p/SMAD4 pathway, hinting that exosomal circ_PTPRA might be used as a potential predicted and therapeutic target for CRC.
Other information
Title:

Exosomal circ_PTPRA inhibits tumorigenesis and promotes radiosensitivity in colorectal cancer by enriching the level of SMAD4 via competitively binding to miR-671-5p.

Journal: Cytotechnology
Published: 2022/2/22
PubMed ID: 35185285