circRNA basic information
circBase ID: hsa_circ_0061140
Name: hsa_circ_C20orf11
Synonym: Circ_0061140
Host Gene: hsa-miR-361-5p
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ovarian epithelial cell line (IOSE-80), OC cell lines (SKOV3, CAOV3, ES-2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-361-5p
Biological function: Downregulation of circ_0061140 impeded proliferation, migration, invasion, EMT, and angiogenesis of OC cells.
Molecular mechanism: Circ_0061140 directly interacted with hsa-miR-361-5p to act as a miRNA sponge. The hsa-miR-361-5p inhibition reversed the si-circ_0061140-induced anti-tumor function in OC cells. RAB1A was a downstream target of hsa-miR-361-5p, and hsa-miR-361-5p served as a tumor repressor in OC via inhibiting the level of RAB1A.
Survival: -
Supported No.:
 3
Description:

All results demonstrated that circ_0061140 promoted OC development by inhibiting miR-361-5p to upregulate the expression of RAB1A.
Other information
Title:

Circ_0061140 Contributes to the Malignant Progression in Ovarian Cancer Cells by Mediating the RAB1A Level Through Sponging miR-361-5p.

Journal: Biochem Genet
Published: 2022/2/20
PubMed ID: 35181843