circRNA basic information
circBase ID: -
Name: hsa_circ_OSBPL10
Synonym: circ_OSBPL10
Host Gene: hsa-miR-299-3p
 
 
 
Disease basic information
DO ID:
 50866
DO name: oral squamous cell carcinoma
Disease details: oral squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human CAL-27 (CRL-2095), SCC-9 (CRL-1629) OSCC cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-299-3p
Biological function: Silencing of circ_OSBPL10 hindered cell proliferation, cell cycle progression, colony formation, migration, invasion, and promoted apoptosis in vitro and diminished tumor growth in vivo.
Molecular mechanism: circ_OSBPL10 directly targeted hsa-miR-299-3p, and circ_OSBPL10 silencing affected cell functional properties in vitro by up-regulating hsa-miR-299-3p. CDK6 was a direct and functional target of hsa-miR-299-3p.
Survival: -
Supported No.:
 1
Description:

Our present findings first demonstrate that circ_OSBPL10 can regulate the functional behaviors of OSCC cells at least partially by miR-299-3p/CDK6 axis, highlighting circ_OSBPL10 as a promising therapeutic target for OSCC.
Other information
Title:

Silencing of circ_OSBPL10 affects the functional behaviors of oral squamous cell carcinoma cells by the miR-299-3p/CDK6 axis.

Journal: Arch Oral Biol
Published: 2022/2/19
PubMed ID: 35180547