circRNA basic information
circBase ID: -
Name: hsa_circ_FURIN
Synonym: Circ_FURIN
Host Gene: hsa-miR-423-5p
 
 
 
Disease basic information
DO ID:
 11612
DO name: polycystic ovary syndrome
Disease details: polycystic ovary syndrome
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human ovarian granulosa-like tumor cells (KGN)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-423-5p
Biological function: Circ_FURIN depletion relieved TTR-induced proliferation inhibition and apoptosis promotion.
Molecular mechanism: circ_FURIN modulated MTM1 expression through hsa-miR-423-5p.
Survival: -
Supported No.:
 2
Description:

Circ_FURIN silencing protected against TTR-induced dysfunction by the miR-423-5p/MTM1 pathway in human ovarian granulosa-like tumor cells.
Other information
Title:

Circ_FURIN knockdown assuages Testosterone-induced human ovarian granulosa-like tumor cell disorders by sponging miR-423-5p to reduce MTM1 expression in polycystic ovary syndrome.

Journal: Reprod Biol Endocrinol
Published: 2022/2/19
PubMed ID: 35177076