circRNA basic information
circBase ID: hsa_circ_0005785
Name: hsa_circ_ANAPC7
Synonym: circANAPC7
Host Gene: hsa-miR-373
 
 
 
Disease basic information
DO ID:
 1793
DO name: pancreatic cancer
Disease details: pancreatic cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human pancreatic cancer cell lines (AsPC-1, MIA PaCa-2, BxPC-3, Panc-1, CFPAC-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-373
Biological function: CircANAPC7 Inhibits Pancreatic Cancer Cell Proliferation
Molecular mechanism: circANAPC7 as a sponge for hsa-miR-373. Mechanistic studies showed that PHLPP2 is a downstream target of ZIP4/hsa-miR-373.
Survival: -
Supported No.:
 1
Description:

This study identified circANAPC7 as a novel tumor suppressor, which functions through the CREB-miR-373-PHLPP2 axis, leading to AKT dephosphorylation, and cyclin D1 and transforming growth factor-beta down-regulation to suppress tumor growth and muscle wasting in pancreatic cancer.
Other information
Title:

Circular RNA ANAPC7 Inhibits Tumor Growth and Muscle Wasting via PHLPP2-AKT-TGF-beta Signaling Axis in Pancreatic Cancer.

Journal: Gastroenterology
Published: 2022/2/18
PubMed ID: 35176309