circRNA basic information
circBase ID: -
Name: hsa_circ_PAG1
Synonym: CircPAG1
Host Gene: hsa-miR-211-5p
 
 
 
Disease basic information
DO ID:
 13328
DO name: diabetic cataract
Disease details: diabetic cataract
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human lens epithelial cell lines (SRA01/04, B-3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-211-5p
Biological function: The upregulation of circPAG1 could attenuate the high glucose-induced inhibition of cell viability and proliferation but promotion of cell apoptosis and oxidative stress.
Molecular mechanism: CircPAG1 served as a hsa-miR-211-5p sponge, and the protective role of circPAG1 was partly achieved by sponging hsa-miR-211-5p. hsa-miR-211-5p targeted E2F3 and circPAG1 upregulated the E2F3 level by absorbing hsa-miR-211-5p.
Survival: -
Supported No.:
 1
Description:

This study clarified that circPAG1 protected human lens epithelial cells from the high glucose-induced cell damages by the mediation of miR-211-5p/E2F3 axis.
Other information
Title:

CircPAG1 interacts with miR-211-5p to promote the E2F3 expression and inhibit the high glucose-induced cell apoptosis and oxidative stress in diabetic cataract.

Journal: Cell Cycle
Published: 2022/2/18
PubMed ID: 35174780