circRNA basic information
circBase ID: hsa_circ_0000285
Name: hsa_circ_HIPK3
Synonym: circ_0000285
Host Gene: hsa-miR-197-3p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SHG-44, A172
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-197-3p
Biological function: circ_0000285-silencing retarded tumor growth both in vitro and in vivo.
Molecular mechanism: This effect was mediated by the binding of circ_0000285 to hsa-miR-197-3p, which silenced CKS1B
Survival: -
Supported No.:
 7
Description:

Thus, circ_0000285 boosted glioma progression by regulating the miR-197-3p/CKS1B axis, highlighting a novel competing endogenous RNA circuit of glioma progression.
Other information
Title:

Regulation of microRNA miR-197-3p/CDC28 protein kinase regulatory subunit 1B (CKS1B) axis by Circular RNA hsa_circ_0000285 promotes glioma progression.

Journal: Bioengineered
Published: 2022/2/18
PubMed ID: 35174774