circRNA basic information
circBase ID: -
Name: hsa_circ_PVT1
Synonym: circPVT1
Host Gene: hsa-miR-24-3p
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human OS cell lines (SAOS-2, KHOS, U2OS, MG63), human osteoblast (hFOB1.19)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-24-3p
Biological function: CircPVT1 was up-regulated in chemoresistant OS cells compared to their parental cells. CircPVT1 inhibition suppressed the proliferation and chemoresistance of OS cells.
Molecular mechanism: CircPVT1 could bind and down-regulate hsa-miR-24-3p. hsa-miR-24-3p negatively regulated the expression of KLF8.
Survival: poor
Supported No.:
 5
Description:

CircPVT1 mediates proliferation and chemoresistance of OS cells via the miR-24-3p/KLF8 axis. The findings may provide guidance for clinical treatment of OS.
Other information
Title:

CircRNA PVT1 promotes proliferation and chemoresistance of osteosarcoma cells via the miR-24-3p/KLF8 axis.

Journal: Int J Clin Oncol
Published: 2022/2/17
PubMed ID: 35171359