circRNA basic information
circBase ID: hsa_circ_0005230
Name: hsa_circ_DNM3OS
Synonym: circ_0005230
Host Gene: hsa-miR-1299
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: GES-1, GC cell lines (SGC-7901, BGC-823, AGS, HGC-27, MKN-45)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-1299
Biological function: Silencing hsa_circ_0005230 significantly decreased GC cell proliferation, invasion and migration capabilities. In addition, the major proteins of EMT (epithelial-mesenchymal transition) relevance have changed.
Molecular mechanism: hsa_circ_0005230/hsa-miR-1299/RHOT1 axis and hsa_circ_0005230 may serve as a sponge for hsa-miR-1299 and indirectly regulate the expression of RHOT1.
Survival: poor
Supported No.:
 1
Description:

Overall, hsa_circ_0005230 could enhance the EMT phenotype by promoting RHOT1 expression through sponging miR-1299, thus affecting the biological behavior of GC. Hsa_circ_0005230 can be easily identified as a potential diagnostic biomarker and assessment prognosis target for GC.
Other information
Title:

Hsa_circ_0005230 is up-regulated and promotes gastric cancer cell invasion and migration via regulating the miR-1299/RHOT1 axis.

Journal: Bioengineered
Published: 2022/2/17
PubMed ID: 35170374