circRNA basic information
circBase ID: hsa_circ_0020123
Name: -
Synonym: Circ_0020123
Host Gene: hsa-miR-140-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human bronchial epithelial cell line (16_BE), NSCLC cell lines (A549, H1299)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-140-3p
Biological function: circ_0020123 promoted DDP resistance in NSCLC cells
Molecular mechanism: Circ_0020123 was identified as a hsa-miR-140-3p sponge. HOXB5 was a downstream target for hsa-miR-140-3p.
Survival: -
Supported No.:
 9
Description:

These results revealed that circ_0020123 promoted DDP resistance in NSCLC cells partly by targeting miR-140-3p/HOXB5 axis, indicating that circ_0020123 might be used as a molecular target in DDP treatment for NSCLC.
Other information
Title:

Circ_0020123 enhances the cisplatin resistance in non-small cell lung cancer cells partly by sponging miR-140-3p to regulate homeobox B5 (HOXB5).

Journal: Bioengineered
Published: 2022/2/17
PubMed ID: 35170372