circRNA basic information
circBase ID: hsa_circ_0003945
Name: hsa_circ_UBAP2
Synonym: circ_0003945
Host Gene: hsa-miR-34c-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: normal liver cells (LO2), hepatoma cells (HepG2), HCC cell line (MHCC97L, MHCC97H, HCCLM3)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-34c-5p
Biological function: overexpression or knockdown of Circ_0003945 promoted or attenuated tumour growth and migration, respectively.
Molecular mechanism: Circ_0003945 might exert as a hsa-miR-34c-5p sponge to upregulate the expression of leucine-rich repeat-containing G protein-coupled receptor 4 (LGR4), activating the beta-catenin pathway, and finally facilitating HCC progression.
Survival: poor
Supported No.:
 4
Description:

In conclusion, Circ_0003945 exerts a tumour-promoting role in HCC cells by regulating the miR-34c-5p/LGR4/beta-catenin axis, which may be a potential target for HCC therapy.
Other information
Title:

Hsa_circ_0003945 promotes progression of hepatocellular carcinoma by mediating miR-34c-5p/LGR4/beta-catenin axis activity.

Journal: J Cell Mol Med
Published: 2022/2/17
PubMed ID: 35170199