circRNA basic information
circBase ID: -
Name: hsa_circ_AXL
Synonym: circ-AXL
Host Gene: hsa-miR-328
 
 
 
Disease basic information
DO ID:
 10652
DO name: Alzheimer disease
Disease details: Alzheimer disease
Species: human
Species details: human
Sample type: cell line
Sample type details: SK-N-SH, SK-SY5Y
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-328
Biological function: Circ-AXL overexpression increased apoptosis rate and declined neurite outgrowth, as well as elevated inflammatory cytokines in cellular AD models; but circ-AXL knockdown exhibited opposite effects.
Molecular mechanism: circ-AXL negatively regulated hsa-miR-328 but positively modulated BACE1, besides, hsa-miR-328 negatively regulated BACE1,
Survival: -
Supported No.:
 3
Description:

Circ-AXL may serve as a potential treatment target via miR-328 mediated BACE1 in AD.
Other information
Title:

Circular RNA AXL increases neuron injury and inflammation through targeting microRNA-328 mediated BACE1 in Alzheimer disease.

Journal: Neurosci Lett
Published: 2022/2/16
PubMed ID: 35167942