circRNA basic information
circBase ID: hsa_circ_0072008
Name: -
Synonym: Circ_0072008,
Host Gene: hsa-miR-545-3p
 
 
 
Disease basic information
DO ID:
 3498
DO name: pancreatic ductal adenocarcinoma
Disease details: pancreatic ductal adenocarcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: SW1990, PANC-1 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-545-3p
Biological function: The circ_0072088 siRNA suppressed cell viability, migration, invasion, extracellular acidification rate (ECAR), lactate production, glucose uptake, and ATP generation, but promoted apoptosis rate and oxygen consumption rate (OCR) in SW1990 and PANC-1 cells._n vivo, circ_0072088 knockdown retarded tumour growth of PANC-1 cells.
Molecular mechanism: hsa-miR-545-3p was targeted by circ_0072008, and SLC7A11 was target of hsa-miR-545-3p.
Survival: -
Supported No.:
 1
Description:

Circ_0072088 elicited oncogenic role in malignant cell progression and glycolysis of PDAC cells through circ_0072088/miR-545-3p/SLC7A11 pathway.HighlightsCirc_0072088 was upregulated in PDAC tumours and was associated with high tumour burden.Blocking circ_0072088 suppressed cell proliferation, migration, invasion, and glycolysis in PDAC cells.Circ_0072088 could directly regulate miR-545-3p, and SLC7A11 was a target of miR-545-3p.Restoring miR-545-3p mimicked the effects of circ_0072088 knockdown in PDAC cell_n vitro.
Other information
Title:

Circ_0072008, an oncogene in pancreatic ductal adenocarcinoma, contributes to tumour cell malignant progression and glycolysis by regulating miR-545-3p/SLC7A11 axis.

Journal: Autoimmunity
Published: 2022/2/16
PubMed ID: 35166634