circRNA basic information
circBase ID: -
Name: hsa_circ_IRAK3
Synonym: circ_IRAK3
Host Gene: hsa-miR-603
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: BC cells (HCC70, MDA-MB-231), human mammary gland epithelial cells (MCF-10A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-603
Biological function: Functional experiments presented that circ_IRAK3 silencing induced BC cell apoptosis, curbed cell proliferation, migration, and invasion in vitro, and decreased tumor growth in vivo.
Molecular mechanism: Mechanistically, circ_IRAK3 could modulate kinesin family member 2A (KIF2A) expression through acting as a microRNA (miR)-603 sponge.
Survival: -
Supported No.:
 2
Description:

circ_IRAK3 exerted a promoting effect on BC progression by modulating the miR-603/KIF2A axis, providing a piece of novel evidence for circ_IRAK3 as a therapeutic target for BC.
Other information
Title:

Circular RNA circ_IRAK3 contributes to tumor growth through upregulating KIF2A via adsorbing miR-603 in breast cancer.

Journal: Cancer Cell Int
Published: 2022/2/16
PubMed ID: 35164763