circRNA basic information
circBase ID: hsa_circ_0001946
Name: hsa_circ_CDR1
Synonym: ciRS-7, CDR1as
Host Gene: hsa-miR-1299
 
 
 
Disease basic information
DO ID:
 2394
DO name: ovarian cancer
Disease details: ovarian cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human OC cell line (SKOV3), CDDP-resistant strains (SKOV3/CDDP)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: PPP1R12B
Associated microRNA: hsa-miR-1299
Biological function: alleviates cisplatin-based chemoresistance
Molecular mechanism: suppressing hsa-miR-1299, miRNA sponge
Survival: -
Supported No.:
 3
Description:

Our findings interpret the underlying mechanisms of the CDR1as/miR-1299/PPP1R12B axis and shed light on the clinical applications for CDDP-chemoresistant OC.
Other information
Title:

Circular RNA CDR1as Alleviates Cisplatin-Based Chemoresistance by Suppressing MiR-1299 in Ovarian Cancer.

Journal: Front Genet
Published: 2022/2/15
PubMed ID: 35154259