circRNA basic information
circBase ID: hsa_circ_0036602
Name: -
Synonym: Circ-0036602
Host Gene: hsa-miR-34a-5p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: CC cell lines (Caski, Siha, C33A), normal cervical epithelial Hacat
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-34a-5p
Biological function: circ0036602 expression significantly correlated with the clinicopathologic characteristics. Knockdown of circ0036602 inhibited CC cell proliferation, migration, and invasion.
Molecular mechanism: circ0036602 could bind to hsa-miR-34-5p and hsa-miR-431-5p to regulate the expression of the target gene HMGB1.
Survival: poor
Supported No.:
 1
Description:

Taken together, our findings suggest that circ0036602 is a tumor-promoting circRNA that promotes CC cells by sponging miR-34-5p and miR-431-5p to regulate HMGB1. Circ0036602 has huge prospects as a potential therapeutic target for CC patients.
Other information
Title:

Circ-0036602 Acts As a Sponge of MiR-34a-5p and MiR-431-5p to Promote Cervical Cancer Proliferation and Invasion.

Journal: J Genomics
Published: 2022/2/12
PubMed ID: 35145563