circRNA basic information
circBase ID: -
Name: hsa_circ_KDM4B
Synonym: CircKDM4B
Host Gene: hsa-miR-675
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MDA-MB-231, MDA-MB-468 , MCF-7, T47D, human umbilical vein endothelial cells (HUVECs)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-675
Biological function: The overexpression of circKDM4B inhibited cell migration and invasion in vitro, while knockdown of circKDM4B induced the opposite effects. In vivo, circKDM4B suppressed tumor growth and metastasis._ircKDM4B inhibited migration and tube formation of human umbilical vein endothelial cells (HUVECs) in vitro and angiogenesis in vivo.
Molecular mechanism: circKDM4B sponged hsa-miR-675 to upregulate the expression of NEDD4-like E3 ubiquitin protein ligase (NEDD4L), which catalyzes ubiquitination of PI3KCA, thereby inhibiting PI3K/AKT and VEGFA secretion.
Survival: -
Supported No.:
 1
Description:

Collectively, these findings uncovered the tumor-suppressor role of circKDM4B in breast cancer, especially in angiogenesis and tumor metastasis, indicating that circKDM4B could be a potential therapeutic target for breast cancer progression.
Other information
Title:

CircKDM4B suppresses breast cancer progression via the miR-675/NEDD4L axis.

Journal: Oncogene
Published: 2022/2/12
PubMed ID: 35145234