circRNA basic information
circBase ID: -
Name: hsa_circ_ZFR
Synonym: circZFR
Host Gene: -
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: cell line, PDX
Sample type details: human normal hepatocyte cell line (L02), HCC cell lines (Huh7, MHCC97L)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: supplementation of CAFs in culture medium could promote DDP resistance of HCC cells.
Molecular mechanism: while CAFs-derived exosomes incubation increased the expression of circZFR, inhibited the STAT3/NF-¦ĘB pathway, promoted tumor growth, and enhanced DDP resistance.
Survival: -
Supported No.:
 4
Description:

In general, CAFs-derived exosomes deliver circZFR to HCC cells, inhibit the STAT3/NF-¦ĘB pathway, and promote HCC development and chemoresistance. The results provided a new sight for the prevention and treatment of chemoresistance in HCC.
Other information
Title:

Cancer-associated fibroblast exosomes promote chemoresistance to cisplatin in hepatocellular carcinoma through circZFR targeting signal transducers and activators of transcription (STAT3)/ nuclear factor -kappa B (NF-kappaB) pathway.

Journal: Bioengineered
Published: 2022/2/11
PubMed ID: 35139763