circRNA basic information
circBase ID: hsa_circ_0134111
Name: hsa_circ_PDE1C
Synonym: circ_0134111
Host Gene: hsa-miR-578
 
 
 
Disease basic information
DO ID:
 90
DO name: degenerative disc disease
Disease details: Intervertebral disc degeneration
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: NP cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-578
Biological function: ectopic expression of circ_0134111 induced proliferation, pro-inflammatory cytokine secretion, and ECM degradation in the NP cells.
Molecular mechanism: circ_0134111 directly interacted with microRNA (miR)-578 in NP cells where elevated expression of circ_0134111 enhanced the ADAMTS-5 and MMP-9 expression.
Survival: -
Supported No.:
 1
Description:

These data suggested that circ_0134111 could promote the progression of IDD through enhancing aberrant NP cell growth, inflammation, and ECM degradation partly via regulating miR-578.
Other information
Title:

Hsa_circ_0134111 promotes intervertebral disc degeneration via sponging miR-578.

Journal: Cell Death Discov
Published: 2022/2/10
PubMed ID: 35136049