circRNA basic information
circBase ID: -
Name: hsa_circ_LECRC
Synonym: circ-LECRC
Host Gene: hsa-miR-135b-5p
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: colorectal cancer cell lines (SW480, SW620, RKO, DLD-1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-135b-5p
Biological function: Circ-LECRC overexpression significantly inhibited CRC cell proliferation, migration, and invasion and promoted apoptosis
Molecular mechanism: circ-LECRC directly binds to hsa-miR-135b-5p and relieve the suppression of its target, Kr¨ąppel-like factor 4 (KLF4).
Survival: -
Supported No.:
 1
Description:

In summary, circ-LECRC regulates KLF4 expression by functioning as a competing endogenous RNA and serves as a brake signal to suppress hyperactivation of oncogenic YAP signalling, leading to tumour growth inhibition in CRC.
Other information
Title:

YAP derived circ-LECRC functions as a brake signal to suppress hyperactivation of oncogenic YAP signalling in colorectal cancer..

Journal: Cancer Lett
Published: 2022/2/9
PubMed ID: 35131381