circRNA basic information
circBase ID: -
Name: hsa_circ_ZFR
Synonym: circ_ZFR
Host Gene: hsa-miR-944
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: SiHa/PTX, Hela/PTX
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-944
Biological function: In PTX-resistant CC cells, knocking down circ_ZFR expression decreased PTX resistance.
Molecular mechanism: circ_ZFR knockdown significantly reduced IL-10 expression via sponging hsa-miR-944, increasing PTX sensitivity in PTX-resistant CC cells.
Survival: -
Supported No.:
 2
Description:

circ_ZFR knockdown has a considerable role in overwhelming CC-associated PTX resistance by modifying the axis of miR-944/IL-10 axis, suggesting that developing a circRNA target-based treatment could be considered prevent CC progression.
Other information
Title:

circ_ZFR Is Linked to Paclitaxel Resistance in Cervical Cancer via miR-944 Sponging and IL-10 Upregulation.

Journal: Anal Cell Pathol (Amst)
Published: 2022/2/8
PubMed ID: 35127342