circRNA basic information
circBase ID: -
Name: hsa_circ_UBAP2
Synonym: circ_UBAP2
Host Gene: hsa-miR-637
 
 
 
Disease basic information
DO ID:
 3347
DO name: osteosarcoma
Disease details: osteosarcoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: OS cells (U-2OS, MG63, SaOS-2, HOS), healthy osteoblasts (hFOB1.19)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-637
Biological function: The overexpression of circ_UBAP2 enhanced the growth, invasion, and migration of OS cells, but suppressed their apoptosis.
Molecular mechanism: hsa-miR-637 served as a downstream target of circ_UBAP2, HMGB2 served as hsa-miR-637s downstream target.
Survival: -
Supported No.:
 5
Description:

Circ_UBAP2 plays a promoting role in OS, and the circ_UBAP2/miR-637/HMGB2 axis is involved in OS progression.
Other information
Title:

Circular RNA circ_UBAP2 facilitates the progression of osteosarcoma by regulating microRNA miR-637/high-mobility group box (HMGB) 2 axis.

Journal: Bioengineered
Published: 2022/2/5
PubMed ID: 35114890