circRNA basic information
circBase ID: hsa_circ_0000518
Name: -
Synonym: circ_0000518
Host Gene: hsa-miR-1225-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: MDA-MB-468, BT549 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1225-3p
Biological function: Circ_0000518 overexpression or inhibition of miR-1225-3p remarkably enhanced the growth, migration as well as invasion of BC cells_n vitro
Molecular mechanism: Circ_0000518 was identified as a molecular sponge of hsa-miR-1225-3p, and it can up-regulate SOX4 mRNA expression via repressing hsa-miR-1225-3p.
Survival: -
Supported No.:
 1
Description:

In conclusion, circ_0000518 is oncogenic in BC and functions through miR-1225-3p/SOX4 axis.
Other information
Title:

Circular RNA circ_0000518 promotes breast cancer progression through the microRNA-1225-3p/SRY-box transcription factor 4 pathway.

Journal: Bioengineered
Published: 2022/2/4
PubMed ID: 35112991