circRNA basic information
circBase ID: -
Name: hsa_circ_RAD23B
Synonym: circ-RAD23B
Host Gene: hsa-miR-142-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: H1299, A549, human bronchial epithelioid cells (16 HBE)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-142-3p
Biological function: Knockdown of circ-RAD23B inhibited proliferation, migration, invasion, angiogenesis and promoted cell cycle arrest and apoptosis in NSCLC cells, and circ-RAD23B knockdown also impeded tumor growth in vivo.
Molecular mechanism: Circ-RAD23B acted as hsa-miR-142-3p sponge to inhibit hsa-miR-142-3p expression and thus enrich the expression of MAP4K3, a target of hsa-miR-142-3p.
Survival: -
Supported No.:
 3
Description:

Circ-RAD23B knockdown inhibited NSCLC development by regulating the miR-142-3p/MAP4K3 axis, which might be associated with the inactivation of the MAPK signaling pathway.
Other information
Title:

Knockdown of circ-RAD23B inhibits non-small cell lung cancer progression via the miR-142-3p/MAP4K3 axis.

Journal: Thorac Cancer
Published: 2022/2/3
PubMed ID: 35106926