circRNA basic information
circBase ID: -
Name: hsa_circ_FAM53B
Synonym: CircFAM53B
Host Gene: hsa-miR-532-3p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: A172, LN18
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-532-3p
Biological function: ircFAM53B up-regulation accelerated cell proliferation, colony formation, invasion and epithelial-mesenchymal transition (EMT), and heightened Bax/Bcl2 ratio.
Molecular mechanism: circFAM53B served as a competitive endogenous RNA (ceRNA) by sponging hsa-miR-532-3p, which targeted proto-oncogene (MET) and receptor tyrosine kinase (c-MET). hsa-miR-532-3p up-regulation delayed glioma development and inactivated the PI3K/AKT axis.
Survival: -
Supported No.:
 1
Description:

Conclusively, circFAM53B aggravated glioma progression by up-regulating the c-MET/PI3K/AKT pathway and down-regulating miR-532-3p. Thus, the circFAM53B/miR-532-3p/c-MET/PI3K/AKT axis is a potential treatment target for glioma.
Other information
Title:

CircFAM53B promotes the proliferation and metastasis of glioma through activating the c-MET/PI3K/AKT pathway via sponging miR-532-3p.

Journal: Cell Cycle
Published: 2022/2/1
PubMed ID: 35100091