circRNA basic information
circBase ID: hsa_circ_0047604
Name: hsa_circ_SMAD2
Synonym: circRNA-0047604
Host Gene: hsa-miR-548o
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Breast cancer cell line (MDA-MB-231, MCF-7), nonmalignant breast epithelial cell line (MCF-10A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-548o
Biological function: Circ_0047604 Can Inhibit Cancer Cell Proliferation and Migration
Molecular mechanism: hsa_circ_0047604 played the role of sponge of hsa-miR-548o. By this way, hsa_circ_0047604 could upregulate DACH1 to inhibit breast cancer.
Survival: better
Supported No.:
 1
Description:

In conclusion, this study revealed that hsa_circ_0047604 acted as a tumor suppressor and regulated breast cancer progression via hsa_circ_0047604-miR-548o-DACH1 axis, which might provide a therapeutic method for breast cancer.
Other information
Title:

The Function of circRNA-0047604 in Regulating the Tumor Suppressor Gene DACH1 in Breast Cancer.

Journal: Biomed Res Int
Published: 2022/2/1
PubMed ID: 35097124