circRNA basic information
circBase ID: -
Name: hsa_circ_ITCH
Synonym: Circ-ITCH
Host Gene: hsa-miR-146b-5p
 
 
 
Disease basic information
DO ID:
 10487
DO name: Hirschsprung disease
Disease details: Hirschsprung disease
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: SH-SY5Y, 293T cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-146b-5p
Biological function: Circ-ITCH overexpression facilitated cell proliferation, migration, and activated MAPK pathway, which were reversed by circRNA-ITCH knockdown.
Molecular mechanism: Circ-ITCH negatively regulated hsa-miR-146b-5p expression. hsa-miR-146b-5p inhibited RET expression.
Survival: -
Supported No.:
 1
Description:

Circ-ITCH overexpression facilitated cell proliferation and migration in HSCR by regulating miR-146b-5p/RET/MAPK axis.
Other information
Title:

Circ-ITCH overexpression promoted cell proliferation and migration in Hirschsprung disease through miR-146b-5p/RET axis.

Journal: Pediatr Res
Published: 2022/1/30
PubMed ID: 35091706