circRNA basic information
circBase ID: -
Name: hsa_circ_VPS13C
Synonym: CircVPS13C
Host Gene: -
 
 
 
Disease basic information
DO ID:
 3829
DO name: pituitary adenoma
Disease details: pituitary adenoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: PDFS cell line
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Silencing circVPS13C inhibits the proliferation of pituitary tumor cells in vitro and in vivo.
Molecular mechanism: circVPS13C inhibits IFITM1 expression through a novel mechanism mainly by competitively interacting with RRBP
Survival: -
Supported No.:
 1
Description:

Our findings suggest that circVPS13C is a critical regulator in the proliferation and development of NFPAs through a novel mechanism, whereby regulating mRNA stability via interacting with ribosome-binding proteins on the endoplasmic reticulum membrane.
Other information
Title:

CircVPS13C promotes pituitary adenoma growth by decreasing the stability of IFITM1 mRNA via interacting with RRBP1.

Journal: Oncogene
Published: 2022/1/30
PubMed ID: 35091683