circRNA basic information
circBase ID: hsa_circ_0001142
Name: hsa_circ_miR-361-3p
Synonym: circ_0001142
Host Gene: hsa-miR-361-3p
 
 
 
Disease basic information
DO ID:
 1612
DO name: breast cancer
Disease details: breast cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal breast cell line (MCF10A), BC cell lines (MDA-MB-231, MDA-MB-453, BT-20, BT-549)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-361-3p
Biological function: The role of exosomes circ_0001142 in the tumor microenvironment and its influence on BC growth, metastasis and macrophage polarization were investigated through in vivo and in vitro studies.
Molecular mechanism: circ_0001142/hsa-miR-361-3p/PIK3CB
Survival: -
Supported No.:
 1
Description:

it was found that the circ_0001142/miR-361-3p/PIK3CB pathway plays an important role in the polarization of macrophages.
Other information
Title:

Endoplasmic reticulum stress promotes breast cancer cells to release exosomes circ_0001142 and induces M2 polarization of macrophages to regulate tumor progression.

Journal: Pharmacol Res
Published: 2022/1/30
PubMed ID: 35091089