circRNA basic information
circBase ID: -
Name: hsa_circ_CHMP5
Synonym: CircCHMP5
Host Gene: hsa-miR-532-5p
 
 
 
Disease basic information
DO ID:
 1936
DO name: atherosclerosis
Disease details: atherosclerosis
Species: human
Species details: human
Sample type: cell line
Sample type details: HUVECs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-532-5p
Biological function: CircCHMP5 knockdown promoted cell cycle, proliferation, and angiogenesis while inhibiting apoptosis and inflammation in ox-LDL-induced HUVECs.
Molecular mechanism: hsa-miR-532-5p could be sponged by circCHMP5, and ROCK2, was a target of hsa-miR-532-5p
Survival: -
Supported No.:
 3
Description:

To sum up, our data showed that circCHMP5 regulated the miR-532-5p/ROCK2 axis to accelerate ox-LDL-induced HUVECs injury, confirming that circCHMP5 might be a potential target for AS treatment.
Other information
Title:

CircCHMP5 Contributes to Ox-LDL-induced Endothelial Cell Injury Through the Regulation of MiR-532-5p/ROCK2 axis.

Journal: Cardiovasc Drugs Ther
Published: 2022/1/28
PubMed ID: 35084579