circRNA basic information
circBase ID: hsa_circ_0006677
Name: hsa_circ_WDR78
Synonym: circ_0006677
Host Gene: hsa-miR-1245a
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human bronchial epithelial cell line (16_BE), lung cancer cell lines (H1299, A549, HCC827, H460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-1245a
Biological function: circ_0006677 overexpression decreased xenograft tumor growth and restrained NSCLC cell proliferation, invasion, migration, stemness, and induced NSCLC cell apoptosis_n vitro.
Molecular mechanism: circ_0006677 functioned as a hsa-miR-1245a sponge and mediated SATB2 expression through adsorbing hsa-miR-1245a.
Survival: -
Supported No.:
 2
Description:

In conclusion, circ_0006677 regulated SATB2-mediated tumor-suppressive effect via acting as a miR-1245a sponge in NSCLC, providing a new mechanism for understanding the progression of NSCLC.
Other information
Title:

Hsa_circ_0006677 regulates special AT-rich binding protein-2-mediated tumor-suppressive effect via functioning as a miR-1245a sponge in non-small cell lung cancer.

Journal: Bioengineered
Published: 2022/1/28
PubMed ID: 35081869