circRNA basic information
circBase ID: -
Name: hsa_circ_SFMBT2
Synonym: circ-SFMBT2
Host Gene: hsa-miR-7-5p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human bronchial epithelial-like cells (HBE), lung cancer cell lines (H1650, H460, A549, H1299)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-7-5p
Biological function: Silencing the overexpression of circ-SFMBT2 and miR-7-5p could inhibit cell proliferation, clone formation and invasion, and also promote apoptosis.
Molecular mechanism: circ-SFMBT2 could target hsa-miR-7-5p, and ADAM10 was the target gene of hsa-miR-7-5p.
Survival: -
Supported No.:
 4
Description:

Silencing circ-SFMBT2 can suppress the proliferation, clone formation, invasion ability and induce apoptosis of NSCLC cells by regulating the miR-7-5p/ADAM10 axis.
Other information
Title:

[Effect of circ-SFMBT2 on the biological behavior of non-small cell lung cancer cells by targeting the miR-7-5p/ADAM10 axis].

Journal: Zhonghua Yi Xue Yi Chuan Xue Za Zhi
Published: 2022/1/26
PubMed ID: 35076912