circRNA basic information
circBase ID: hsa_circ_0074269
Name: hsa_circ_ANKHD1-EIF4EBP3
Synonym: circ_0074269
Host Gene: hsa-miR-485-5p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: Ect1/E6E7 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-485-5p
Biological function: Silencing of circ_0074269 elevated DDP sensitivity, repressed DDP-resistant cervical cancer cell proliferation, and induced DDP-resistant cervical cancer cell apoptosis in vivo and in vitro and curbed DDP-resistant cervical cancer cell migration in vitro.
Molecular mechanism: circ_0074269 could regulate DDP resistance via regulating TUFT1 expression via sponging hsa-miR-485-5p.
Survival: -
Supported No.:
 1
Description:

Circ_0074269 facilitated DDP resistance via elevating TUFT1 expression via sponging miR-485-5p, proving novel evidence to offer circ_0074269 as a target for cervical cancer treatment.
Other information
Title:

Hsa_circ_0074269-mediated Upregulation of TUFT1 Through miR-485-5p Increases Cisplatin Resistance in Cervical Cancer.

Journal: Reprod Sci
Published: 2022/1/26
PubMed ID: 35075616