circRNA basic information
circBase ID: -
Name: hsa_circ_VAMP3
Synonym: circVAMP3
Host Gene: -
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: HEK293T, SMMC_7721, Huh7, HeLa, A549 cells
circRNA-disease information
Detected method:
Q
S
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: circVAMP3 negatively regulates the proliferation and metastasis of HCC cells
Molecular mechanism: driving phase separation of CAPRIN1 and promoting stress granule formation in cells, which can downregulate the protein level of Myc proto-oncogene protein by inhibiting c-Myc translation.
Survival: better
Supported No.:
 1
Description:

circVAMP3 is a potential prognostic indicator for HCC and may serve as a therapeutic target for HCC treatment.
Other information
Title:

circVAMP3 Drives CAPRIN1 Phase Separation and Inhibits Hepatocellular Carcinoma by Suppressing c-Myc Translation.

Journal: Adv Sci (Weinh)
Published: 2022/1/25
PubMed ID: 35072355