circRNA basic information
circBase ID: -
Name: -
Synonym: CircRNA_400029
Host Gene: hsa-miR-1285-3p
 
 
 
Disease basic information
DO ID:
 4362
DO name: cervical cancer
Disease details: cervical cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: CC cell lines (SiHa, HeLa, CaSki, C-33A), human cervical epithelial immortalized cell line (H8)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1285-3p
Biological function: Knockdown circRNA_400029 inhibited cell proliferation, migration and invasion while induced cell apoptosis.
Molecular mechanism: hsa-miR-1285-3p targeted circRNA_400029 and down-regulated of hsa-miR-1285-3p could reverse the effects of circRNA_400029 weak-expression on progression and apoptosis of CC cells. Moreover, TLN1 was up-regulated in CC cells and identified as a direct target of hsa-miR-1285-3p.
Survival: -
Supported No.:
 1
Description:

The overexpressed circRNA_400029 promoted CC proliferation, migration and invasion while deduced apoptosis by sponging miR-1285-3p to regulate TLN1. CircRNA_400029 was a potential onco-circRNA in CC, and might be a promised therapy target.
Other information
Title:

CircRNA_400029 promotes the aggressive behaviors of cervical cancer by regulation of miR-1285-3p/TLN1 axis.

Journal: J Cancer
Published: 2022/1/25
PubMed ID: 35069901