circRNA basic information
circBase ID: -
Name: hsa_circ_CCDC66
Synonym: circCCDC66
Host Gene: hsa-miR-370
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: RKO, HCT-116
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-370
Biological function: This study showed that circRNA CCDC66 was overexpressed in CRC tissues, and after knockdown, it inhibited the proliferation, migration, and invasion of CRC cells
Molecular mechanism: circCCDC66 and hsa-miR-370, as well as between hsa-miR-370 and murine double minute 4 (MDM4).
Survival: -
Supported No.:
 4
Description:

In summary, our results indicate that circCCDC66 is a key upregulation of CRC. circCCDC66 upregulates MDM4 through competitive binding to miR-370, thereby enhancing the metastatic ability of CRC cells and promoting the development of CRC.
Other information
Title:

Circular RNA CCDC66 Improves Murine Double Minute 4 (MDM4) Expression through Targeting miR-370 in Colorectal Cancer.

Journal: Comput Math Methods Med
Published: 2022/1/25
PubMed ID: 35069793