circRNA basic information
circBase ID: -
Name: hsa_circ_TLK1
Synonym: circTLK1
Host Gene: hsa-miR-26a-5p
 
 
 
Disease basic information
DO ID:
 6713
DO name: cerebrovascular disease
Disease details: ischemic stroke
Species: human
Species details: human
Sample type: PDX
Sample type details: -
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-26a-5p
Biological function: circTLK1 knockdown decreased infarct volume and neurological impairment in MCAO mouse models and relieved OGD/R-induced neuronal injury_n vitro
Molecular mechanism: circTLK1 and hsa-miR-26a-5p were co-located in the N2a cell cytoplasm. circTLK1 regulated PTEN as a sponge of hsa-miR-26a-5p.
Survival: -
Supported No.:
 3
Description:

In conclusion, circTLK1 knockdown relieved IS via the miR-26a-5p/PTEN/IGF-1 R/GLUT1 axis. These results may provide a new direction to IS potential therapeutic targets.
Other information
Title:

Knockdown of circular RNA tousled-like kinase 1 relieves ischemic stroke in middle cerebral artery occlusion mice and oxygen-glucose deprivation and reoxygenation-induced N2a cell damage.

Journal: Bioengineered
Published: 2022/1/25
PubMed ID: 35067172