circRNA basic information
circBase ID: -
Name: hsa_circ_CBFB
Synonym: CircCBFB
Host Gene: hsa-miR-424-5p
 
 
 
Disease basic information
DO ID:
 684
DO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: human HCC cell lines (HepG2, SMMC-7721, Huh-7, MHCC97H, HCCLM3), normal hepatocytes (THLE2)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-424-5p
Biological function: Transfection of pcDNA3.1-CircCBFB, miR-424-5p inhibitor, or pcDNA3.1-ATG14 into HCC cells facilitated HCC cell proliferation and autophagy, while suppressing cell apoptosis, evidenced by elevated cell viability
Molecular mechanism: hsa-miR-424-5p was a target gene of circCBFB, and hsa-miR-424-5p negatively mediated ATG14.
Survival: -
Supported No.:
 1
Description:

CircCBFB inhibits miR-424-5p and upregulates ATG14, thus promoting HCC cell proliferation and autophagy.
Other information
Title:

CircCBFB is a mediator of hepatocellular carcinoma cell autophagy and proliferation through miR-424-5p/ATG14 axis.

Journal: Immunol Res
Published: 2022/1/24
PubMed ID: 35066780