circRNA basic information
circBase ID: hsa_circ_0001020
Name: hsa_circ_UGP2
Synonym: circ_0001020
Host Gene: hsa-miR-29c-3p
 
 
 
Disease basic information
DO ID:
 0060903
DO name: thrombosis
Disease details: deep vein thrombosis
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: neutrophils, EPCs were isolated from volunteers.
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-29c-3p
Biological function: In DVT mice, hsa_circ_0001020 knockdown suppressed thrombosis and promoted homing ability of EPCs into thrombi.
Molecular mechanism: Hsa_circ_0001020 sponged hsa-miR-29c-3p to promote MDM2 expression thus inhibited EPC migration, invasion and tube formation.
Survival: -
Supported No.:
 1
Description:

Our finding demonstrated a novel signaling pathway involving hsa_circ_0001020, miR-29c-3p, MDM2, which might be a potential therapeutic target for DVT.
Other information
Title:

Hsa_circ_0001020 accelerates the lower extremity deep vein thrombosis via sponging miR-29c-3p to promote MDM2 expression.

Journal: Thromb Res
Published: 2022/1/24
PubMed ID: 35066205