circRNA basic information
circBase ID: -
Name: hsa_circ_ATIC
Synonym: Circ-ATIC
Host Gene: hsa-miR-326
 
 
 
Disease basic information
DO ID:
 3748
DO name: esophagus squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human ESCC cell lines (KYSE-450, Eca-109), esophageal epithelial cell line (HET-1A)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-326
Biological function: Silenced circ-ATIC suppressed the proliferation, migration, invasion, promoted the apoptosis and oxidative stress of ESCC cells.
Molecular mechanism: circ-ATIC could sponge hsa-miR-326, and hsa-miR-326 could target ID1.
Survival: -
Supported No.:
 2
Description:

Our study showed that circ-ATIC facilitated the progression of ESCC by regulating the miR-326/ID1 axis, indicating that circ-ATIC might be a target for ESCC treatment.
Other information
Title:

Circ-ATIC Serves as a Sponge of miR-326 to Accelerate Esophageal Squamous Cell Carcinoma Progression by Targeting ID1.

Journal: Biochem Genet
Published: 2022/1/23
PubMed ID: 35064360