circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF532
Synonym: circZNF532
Host Gene: hsa-miR-1243
 
 
 
Disease basic information
DO ID:
 8947
DO name: diabetic retinopathy
Disease details: Diabetic retinopathy
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: hRMECs
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: CARM1
Associated microRNA: hsa-miR-1243
Biological function: Down-regulation of circZNF532 restrained HG-induced hRMECs proliferation, migration, invasion, angiogenesis and inflammation via regulating miR-1243.
Molecular mechanism: miR-1243 competitively bound to circZNF532 and CARM1.
Survival: -
Supported No.:
 1
Description:

circZNF532 facilitated HG-induced angiogenesis and inflammation in hRMECs via modulating the miR-1243/CARM1 pathway, suggesting that circZNF532 might be a potential biomarker for DR treatment.
Other information
Title:

Circular RNA circZNF532 facilitates angiogenesis and inflammation in diabetic retinopathy via regulating miR-1243/CARM1 axis.

Journal: Diabetol Metab Syndr
Published: 2022/1/23
PubMed ID: 35063035