circRNA basic information
circBase ID: -
Name: hsa_circ_ST3GAL6
Synonym: circST3GAL6
Host Gene: hsa-miR-300
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human GC cell lines (MGC_803, BGC_823, MKN_45, SGC_7901), normal stomach mucosa epithelium cells (GES_1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-300
Biological function: Overexpression of circST3GAL6 inhibited the malignant behaviours of GC cells, which was mediated by inducing apoptosis and autophagy.
Molecular mechanism: we demonstrated that circST3GAL6 regulated FOXP2 through the hsa-miR-300 sponge.
Survival: -
Supported No.:
 1
Description:

In conclusion, our results suggested that circST3GAL6 played a tumour suppressive role in gastric cancer through miR-300/FOXP2 axis and regulated apoptosis and autophagy through FOXP2-mediated transcriptional inhibition of the MET axis, which may become a potential target for GC therapy.
Other information
Title:

The novel role of circular RNA ST3GAL6 on blocking gastric cancer malignant behaviours through autophagy regulated by the FOXP2/MET/mTOR axis.

Journal: Clin Transl Med
Published: 2022/1/22
PubMed ID: 35061934