circRNA basic information
circBase ID: hsa_circ_0005835
Name: -
Synonym: circ_0005835
Host Gene: hsa-miR-576-3p
 
 
 
Disease basic information
DO ID:
 10652
DO name: Alzheimer disease
Disease details: Alzheimer disease
Species: human
Species details: human
Sample type: cell line
Sample type details: SH-SY5Y, BV2 cells
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-576-3p
Biological function: Knockdown of circ_0005835 could downregulate neuroinflammation in BV2 cells. Moreover, knockdown of circ_0005835 promoted neural stem cells (NSC) proliferation and differentiate to neuron.
Molecular mechanism: circ_0005835 promoted NSC proliferation and differentiate to neuron via sponging hsa-miR-576-3p.
Survival: -
Supported No.:
 1
Description:

These data suggested that circ_0005835 promoted AD development through regulating miR-576-3p expression.
Other information
Title:

Circular RNA circ_0005835 promotes promoted neural stem cells proliferation and differentiate to neuron and inhibits inflammatory cytokines levels through miR-576-3p in Alzheimer disease.

Journal: Environ Sci Pollut Res Int
Published: 2022/1/22
PubMed ID: 35060046