circRNA basic information
circBase ID: -
Name: hsa_circ_ZNF131
Synonym: circZNF131
Host Gene: hsa-miR-186-5p
 
 
 
Disease basic information
DO ID:
 10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal gastric epithelial cell line (GES-1), GC cell lines (AGS, HGC-27)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-186-5p
Biological function: Functional analyses showed that circZNF131 knockdown suppressed GC cell colony formation ability, migration, invasion and glycolysis metabolism, and induced cell apoptosis.
Molecular mechanism: Mechanically, hsa-miR-186-5p was a target of circZNF131, and hsa-miR-186-5p could bind to PFKFB2.
Survival: -
Supported No.:
 1
Description:

circZNF131 could exert an oncogenic role in GC malignant development through the miR-186-5p/PFKFB2 axis, which might provide novel targets for GC treatment.
Other information
Title:

Knockdown circZNF131 Inhibits Cell Progression and Glycolysis in Gastric Cancer Through miR-186-5p/PFKFB2 Axis.

Journal: Biochem Genet
Published: 2022/1/22
PubMed ID: 35059934