circRNA basic information
circBase ID: hsa_circ_0002623
Name: -
Synonym: Circ_0002623
Host Gene: hsa-miR-1276
 
 
 
Disease basic information
DO ID:
 11054
DO name: urinary bladder cancer
Disease details: bladder cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human BCa cell lines (J82, RT4, T24, 5637, HT_1376), immortalized bladder epithelial cells (SV_HUC_1)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-1276
Biological function: Circ_0002623 positively regulated BCa cell proliferation, migration, and cell cycle progression.
Molecular mechanism: circ_0002623 could competitively bind with hsa-miR-1276 to increase the expression of SMAD2, the target gene of hsa-miR-1276.
Survival: -
Supported No.:
 1
Description:

circ_0002623 could regulate the expression of TGF-beta and WNT1 via modulating miR-1276 and SMAD2. This study helps to better understand the molecular mechanism underlying BCa progression.
Other information
Title:

Circ_0002623 promotes bladder cancer progression by regulating the miR-1276/SMAD2 axis.

Journal: Cancer Sci
Published: 2022/1/21
PubMed ID: 35048477