circRNA basic information
circBase ID: -
Name: hsa_circ_ITFG2
Synonym: circITFG2
Host Gene: hsa-miR-1204
 
 
 
Disease basic information
DO ID:
 9256
DO name: colorectal cancer
Disease details: colorectal cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: Colon adenocarcinoma cells (SW620, LoVo).normal human colonic epithelial cells (NCM460)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-1204
Biological function: CircITFG2 knockdown or miR-1204 overexpression abolished lidocaine-induced inhibition in proliferation, metastasis and promotion in apoptosis in CRC cells.
Molecular mechanism: CircITFG2 sponged hsa-miR-1204 to regulate SOCS3 expression in lidocaine-treated CRC cells.
Survival: -
Supported No.:
 1
Description:

Lidocaine hindered CRC progression by circITFG2/miR-1204/SOCS2 axis. This finding might beat a path in improving CRC therapy.
Other information
Title:

Lidocaine hampers colorectal cancer process via circITFG2/miR-1204/SOCS2 axis.

Journal: Anticancer Drugs
Published: 2022/1/20
PubMed ID: 35045525