circRNA basic information
circBase ID: hsa_circ_0007580
Name: -
Synonym: Circ_0007580
Host Gene: hsa-miR-598
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human NSCLC cell lines (A549, H1299), a normal bronchial epithelial cell line (BEAS_2B)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-598
Biological function: Functional experiments suggested that circ_0007580 silencing could improve the radiosensitivity of cells by suppressing cell proliferation and increasing apoptosis.
Molecular mechanism: hsa-miR-598 was confirmed to be a target of circ_0007580, and its inhibitor could reverse the regulation of circ_0007580 on the radiosensitivity of NSCLC cells. hsa-miR-598 was found to target THBS2.
Survival: -
Supported No.:
 1
Description:

Our results revealed that circ_0007580 might be a target for improving the radiosensitivity of NSCLC, which was mainly achieved by regulating the miR-598/THBS2 axis.
Other information
Title:

Circ_0007580 knockdown strengthens the radiosensitivity of non-small cell lung cancer via the miR-598-dependent regulation of THBS2.

Journal: Thorac Cancer
Published: 2022/1/20
PubMed ID: 35044104