circRNA basic information
circBase ID: hsa_circ_0006220
Name: hsa_circ_TADA2A
Synonym: Circ_0006220
Host Gene: hsa-miR-203-3p
 
 
 
Disease basic information
DO ID:
 3908
DO name: lung non-small cell carcinoma
Disease details: non-small cell lung cancer
Species: human
Species details: human
Sample type: tissue, cell line
Sample type details: normal human bronchial epithelial cells (HBE cell line), human embryonic kidney cells (HEK293T cell line), NSCLC cell lines (H1299, H1975, A549, H2228)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-203-3p
Biological function: It was revealed that circ_0006220 overexpression facilitated NSCLC cell growth, migration, and invasion
Molecular mechanism: hsa-miR-203-3p was identified as a downstream target of circ_0006220, and circ_0006220 could sponge hsa-miR-203-3p, RGS17 was identified as a downstream target of hsa-miR-203-3p and was positively modulated by circ_0006220.
Survival: -
Supported No.:
 6
Description:

Circ_0006220 up-regulates RGS17 expression by adsorbing miR-203-3p to promote NSCLC development.
Other information
Title:

Circ_0006220 promotes non-small cell lung cancer progression via sponging miR-203-3p and regulating RGS17 expression.

Journal: Hum Exp Toxicol
Published: 2022/1/19
PubMed ID: 35041543