circRNA basic information
circBase ID: hsa_circ_0001495
Name: hsa_circ_CCNB1
Synonym: circCCNB1
Host Gene: hsa-miR-516b-5p
 
 
 
Disease basic information
DO ID:
 0060108
DO name: brain glioma
Disease details: glioma
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human astrocytes (HA)_nd glioma cells (U251, U87, T98, A172)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-516b-5p
Biological function: EIF4A3 positively regulated circCCNB1 expression. CircCCNB1 knockdown repressed glioma cell proliferation and cell cycle process in vitro and blocked tumor growth in vivo.
Molecular mechanism: CircCCNB1 regulated glioma cell progression and CCND1 expression by hsa-miR-516b-5p and HuR.
Survival: -
Supported No.:
 1
Description:

circCCNB1 aggravated glioma cell growth by elevating CCND1 through targeting miR-516b-5p and HuR.
Other information
Title:

EIF4A3-induced circCCNB1 (hsa_circ_0001495) promotes glioma progression by elevating CCND1 through interacting miR-516b-5p and HuR.

Journal: Metab Brain Dis
Published: 2022/1/18
PubMed ID: 35038081