circRNA basic information
circBase ID: hsa_circ_0000190
Name: hsa_circ_CNIH4
Synonym: Circ_0000190
Host Gene: hsa-miR-382-5p
 
 
 
Disease basic information
DO ID:
10534
DO name: stomach cancer
Disease details: gastric cancer
Species: human
Species details: human
Sample type: tissue, cell line, PDX
Sample type details: human normal gastric epithelial cell line (GES-1), GC cell lines (AGS, KATO III, MKN1, HGC27)
circRNA-disease information
Detected method:
Q
Detected method confidence High
Expression pattern:
DN
Associated gene: -
Associated microRNA: hsa-miR-382-5p
Biological function: circ_0000190 overexpression inhibited the proliferation, migration and invasion and promoted Erastin- or ras selective lethal 3 (RSL3)-mediated ferroptosis in GC cells.
Molecular mechanism: hsa-miR-382-5p was a target of circ_0000190, and circ_0000190 suppressed GC progression partly via serving as hsa-miR-382-5p sponge. ZNRF3 was a target of hsa-miR-382-5p, and hsa-miR-382-5p accelerated the proliferation, motility and restrained the ferroptosis of GC cells partly via regulating ZNRF3.
Survival: better
Supported No.:
3
Description:

Circ_0000190 suppressed GC progression via miR-382-5p-dependent regulation of ZNRF3.

Other information
Title:

Circ_0000190 sponges miR-382-5p to suppress cell proliferation and motility and promote cell death by targeting ZNRF3 in gastric cancer.

Journal: J Biochem
Published: 2022/1/18
PubMed ID: 35037032